Calotropis induced ocular toxicity

Amphotericin B induced ocular toxicity in cryptococcal meningitis.

We report a case of acute visual loss after a test dose (1 mg) of intravenous amphotericin B administered to a patient with systemic lupus erythematosus and with cryptococcal meningitis. Her visual acuity was normal prior to the injection of amphotericin B. The meningitis subsequently responded to miconazole and flucytosine treatment. Our findings suggest that amphotericin B should be withheld ...

Ocular pigmentation protects the rabbit retina from gentamicin-induced toxicity.

PURPOSE This study was designed to investigate the possibility that gentamicin-induced retinal toxicity is dependent on ocular pigmentation by comparing the effects of the drug on the functional and morphologic integrity of the retina in albino and pigmented rabbits. METHODS In each rabbit, a solution of gentamicin sulfate was injected into the vitreous of one eye, and saline was injected int...

Ocular toxicity of ethambutol.

OBJECTIVE To review the literature on ocular toxicity of ethambutol--its background, clinical presentation, toxicity characteristics, management, monitoring, and preventive measures. DATA SOURCES Literature search of Medline from 1962 to May 2005. STUDY SELECTION All related literature in English using the search formula: (ethambutol OR myambutol) AND (eye* OR ophthal* OR ocular) AND (adver...

Ocular toxicity of hydroxychloroquine.

OBJECTIVES To review the types, incidence, pathogenesis, risk factors, and clinical characteristics of hydroxychloroquine ocular toxicity and current views about its screening and management. DATA SOURCES Literature search of Medline up to May 2005. STUDY SELECTION Key words for the literature search were 'hydroxychloroquine', 'chloroquine', 'ocular', 'toxicity', 'retinopathy', and 'screeni...

Ocular toxicity from ethambutol.